Anti–DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern

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Anti–DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern

We have studied the regulation of anti-DNA B cells in transgenic mice with a heavy chain transgene (3H9H/56R). This transgene codes for a heavy chain that forms anti-double-stranded DNA (dsDNA) antibody when paired with most members of the endogenous Vkappa repertoire, but certain L chains, referred to as Vkappa editors, do not sustain dsDNA binding in combination with 3H9H/56R. In the nonautoi...

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Altered expression and editing of miRNA-100 regulates iTreg differentiation

RNA editing of miRNAs, especially in the seed region, adds another layer to miRNA mediated gene regulation which can modify its targets, altering cellular signaling involved in important processes such as differentiation. In this study, we have explored the role of miRNA editing in CD4(+) T cell differentiation. CD4(+) T cells are an integral component of the adaptive immune system. Naïve CD4(+...

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Editing and escape from editing in anti-DNA B cells.

Tolerance to dsDNA is achieved through editing of Ig receptors that react with dsDNA. Nevertheless, some B cells with anti-dsDNA receptors escape editing and migrate to the spleen. Certain anti-dsDNA B cells that are recovered as hybridomas from the spleens of anti-dsDNA H chain transgenic mice also bind an additional, Golgi-associated antigen. B cells that bind this antigen accumulate intracel...

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B cells keep on editing

proteins fashioned by swollen cardiomyocytes. The mice and their heart muscle cells also had a higher-than-normal death rate. Loss of Notch also spurred more heart stem cells to differentiate. Notch might allow the heart to conserve these cells. The Notch pathway triggers stem cell proliferation in skeletal muscle, and the pathway shortcircuits as we age. The researchers say that it’s possible ...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 2002

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.20021560